Combined Effect of Platelets and Anidulafungin against Aspergillus fumigatus Infections
نویسندگان
چکیده
منابع مشابه
Anidulafungin in combination with amphotericin B against Aspergillus fumigatus.
We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in co...
متن کاملPharmacodynamics of anidulafungin against clinical Aspergillus fumigatus isolates in a nonneutropenic murine model of disseminated aspergillosis.
Azole resistance is an emerging increasing problem in Aspergillus fumigatus that results in treatment failure. Alternative treatments may improve the therapeutic outcome in patients with azole-resistant invasive aspergillosis (IA). Little is known about the in vivo efficacy of the echinocandin anidulafungin (AFG) in IA. The in vivo efficacy of 2.5, 5, 10, and 20 mg/kg of body weight AFG was ass...
متن کاملPotential synergistic activity of antimycotic substances in combination with human platelets against Aspergillus fumigatus.
of the two tested compounds. While the safety of squalamine has been demonstrated in clinical studies, no in vitro or in vivo toxicity studies have been reported for synthesized aminosterols. Nevertheless, since ASDs were reported to act as membrane disruptors, such a wide antimicrobial spectrum may encompass a potential toxicity that should be further investigated. Overall, we have demonstrate...
متن کاملPrevalence of specific immunoglobulin E and G against Aspergillus fumigatus in patients with asthma
Background and Purpose: Aspergillus fumigatus as a ubiquitous fungus can be found in the respiratory tract of the asthmatic and healthy people. The inhalation of Aspergillus spores leads to an immune response in individuals with asthma and results in the aggravation of the clinical symptoms. The present study aimed to investigate the prevalence of specific immunoglobulin E and G (IgE and IgG) a...
متن کاملActivation of platelets by Aspergillus fumigatus and potential role of platelets in the immunopathogenesis of Aspergillosis.
Aspergillus fumigatus is the most frequent cause of invasive mold infections worldwide. Platelets contribute to inflammation and promote thrombosis, characteristically seen in aspergillosis, and might be involved both in antifungal defense and in the histopathological process. In the experiments reported here, in vitro activation of platelets by conidia, swollen conidia, and hyphae from A. fumi...
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ژورنال
عنوان ژورنال: Journal of Infectious Diseases and Therapy
سال: 2017
ISSN: 2332-0877
DOI: 10.4172/2332-0877.1000334